The Hydroshear Plus is an automated, Point-sink shearer, offering a simple and easy-to-use, reproducible and controllable method of fragmenting DNA. The Hydroshear creates and controls hydrodynamic forces that work in conjunction with its innovative shearing assembly to shear DNA. A wide range of DNA samples are compatible with the Hydroshear, and the shearing parameters can be adusted to product specific fragment lengths of DNA.

The Hydroshear design is optimized to reduce the volume of sample required and to speed processing time. 90% of the sheared DNA fragments fall within a twofold size distribution that is highly reproducible over a wide range of temperatures, DNA concentrations, and initial DNA sizes.

The Hydroshear cloning efficiency of the sheared DNA is excellent without end repair. The distribution of the assembled sequences is random, and there is no sequence bias at the ends of the sheared fragments that have been cloned.

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