Discover the music in DNA methylation.

The relationships between DNA methylation and gene expression, tumorigenesis and disease progression are complex and they can appear discordant. Pyro Q-CpG™ is a quantitative, high-resolution analysis solution for CpG methylation which can harmonize methylation data with observed biological phenomena. Analyze single CpG sites as easily as multiple sites, and even estimate global methylation. You’ll add greater resonance to your research with quantitative data that is reproducible and consistent, measure for measure.

Pyro Q-CpG™

Pyro Q-CpG from Biotage offers these advantages for methylation analysis:

• Consistent, individual quantification of multiple CpG sites
• Versatile for a range of analyses, from single CpGs to global methylation
• Easy to communicate data: methylation levels are presented in sequence context
• Built-in QC for bisulfite treatment
• Suitable for analysis of fresh-frozen, fixed and paraffin-embedded specimens
• Robust and flexible assays, ready-made and custom-designed
• High throughput: 96 samples analyzed in parallel in 1 hour after PCR

Pyro Q-CpG is a complete solution for methylation analysis comprising instrumentation, chemistry, software, assays and analysis services. Based on Pyrosequencing® technology, Pyro Q-CpG builds on the solid scientific and technical knowledge of our own staff, as well as routine collaborations with cancer geneticists.

Software

Biotage has developed a new software platform specifically for analyzing methylation in multiple consecutive CpG sites. The software is compatible with all existing instrument platforms. Software performs analysis of 96 samples in parallel and of as many CpG sites that can be sequenced in a single run.